这是我的解决方案，也做touppercase使用一个参数和检查其他可能的空白和在提供的字符串大写。

var a = "rgb(10, 128, 255)";
var b = "rgb( 10, 128, 255)";
var c = "rgb(10, 128, 255 )";
var d = "rgb ( 10, 128, 255 )";
var e = "RGB ( 10, 128, 255 )";
var f = "rgb(10,128,255)";
var g = "rgb(10, 128,)";

var rgbToHex = (function () {
    var rx = /^rgb\s*\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)$/i;

    function pad(num) {
        if (num.length === 1) {
            num = "0" + num;
        }

        return num;
    }

    return function (rgb, uppercase) {
        var rxArray = rgb.match(rx),
            hex;

        if (rxArray !== null) {
            hex = pad(parseInt(rxArray[1], 10).toString(16)) + pad(parseInt(rxArray[2], 10).toString(16)) + pad(parseInt(rxArray[3], 10).toString(16));

            if (uppercase === true) {
                hex = hex.toUpperCase();
            }

            return hex;
        }

        return;
    };
}());

console.log(rgbToHex(a));
console.log(rgbToHex(b, true));
console.log(rgbToHex(c));
console.log(rgbToHex(d));
console.log(rgbToHex(e));
console.log(rgbToHex(f));
console.log(rgbToHex(g));

据jsfiddle

jsperf的速度比较

进一步的改进可以是trim() rgb字符串

var rxArray = rgb.trim().match(rx),

从bootstrap颜色选择器获取的颜色类

// Color object
var Color = function(val) {
    this.value = {
        h: 1,
        s: 1,
        b: 1,
        a: 1
    };
    this.setColor(val);
};

Color.prototype = {
    constructor: Color,

    //parse a string to HSB
    setColor: function(val){
        val = val.toLowerCase();
        var that = this;
        $.each( CPGlobal.stringParsers, function( i, parser ) {
            var match = parser.re.exec( val ),
            values = match && parser.parse( match ),
            space = parser.space||'rgba';
            if ( values ) {
                if (space === 'hsla') {
                    that.value = CPGlobal.RGBtoHSB.apply(null, CPGlobal.HSLtoRGB.apply(null, values));
                } else {
                    that.value = CPGlobal.RGBtoHSB.apply(null, values);
                }
                return false;
            }
        });
    },

    setHue: function(h) {
        this.value.h = 1- h;
    },

    setSaturation: function(s) {
        this.value.s = s;
    },

    setLightness: function(b) {
        this.value.b = 1- b;
    },

    setAlpha: function(a) {
        this.value.a = parseInt((1 - a)*100, 10)/100;
    },

    // HSBtoRGB from RaphaelJS
    // https://github.com/DmitryBaranovskiy/raphael/
    toRGB: function(h, s, b, a) {
        if (!h) {
            h = this.value.h;
            s = this.value.s;
            b = this.value.b;
        }
        h *= 360;
        var R, G, B, X, C;
        h = (h % 360) / 60;
        C = b * s;
        X = C * (1 - Math.abs(h % 2 - 1));
        R = G = B = b - C;

        h = ~~h;
        R += [C, X, 0, 0, X, C][h];
        G += [X, C, C, X, 0, 0][h];
        B += [0, 0, X, C, C, X][h];
        return {
            r: Math.round(R*255),
            g: Math.round(G*255),
            b: Math.round(B*255),
            a: a||this.value.a
        };
    },

    toHex: function(h, s, b, a){
        var rgb = this.toRGB(h, s, b, a);
        return '#'+((1 << 24) | (parseInt(rgb.r) << 16) | (parseInt(rgb.g) << 8) | parseInt(rgb.b)).toString(16).substr(1);
    },

    toHSL: function(h, s, b, a){
        if (!h) {
            h = this.value.h;
            s = this.value.s;
            b = this.value.b;
        }
        var H = h,
        L = (2 - s) * b,
        S = s * b;
        if (L > 0 && L <= 1) {
            S /= L;
        } else {
            S /= 2 - L;
        }
        L /= 2;
        if (S > 1) {
            S = 1;
        }
        return {
            h: H,
            s: S,
            l: L,
            a: a||this.value.a
        };
    }
};

如何使用

var color = new Color("RGB(0,5,5)");
color.toHex()

这个看起来好一点:

var rgb = $('#selector').css('backgroundColor').match(/\d+/g);
var r   = parseInt(rgb[0], 10);
var g   = parseInt(rgb[1], 10);
var b   = parseInt(rgb[2], 10);
var hex = '#'+ r.toString(16) + g.toString(16) + b.toString(16);

更简洁的一句话:

var rgb = $('#selector').css('backgroundColor').match(/\d+/g);
var hex = '#'+ Number(rgb[0]).toString(16) + Number(rgb[1]).toString(16) + Number(rgb[2]).toString(16);

强制jQuery总是返回十六进制:

$.cssHooks.backgroundColor = {
    get: function(elem) {
        if (elem.currentStyle)
            var bg = elem.currentStyle["backgroundColor"];
        else if (window.getComputedStyle) {
            var bg = document.defaultView.getComputedStyle(elem,
                null).getPropertyValue("background-color");
        }
        if (bg.search("rgb") == -1) {
            return bg;
        } else {
            bg = bg.match(/\d+/g);
            function hex(x) {
                return ("0" + parseInt(x).toString(16)).slice(-2);
            }
            return "#" + hex(bg[0]) + hex(bg[1]) + hex(bg[2]);
        }
    }
}

短

// c - color str e.g."rgb(12,233,43)", result color hex e.g. "#0ce92b"
let rgb2hex=c=>'#'+c.match(/\d+/g).map(x=>(+x).toString(16).padStart(2,0)).join``

// RGB -颜色STR，例如" RGB(12,233,43)"，结果颜色十六进制，例如“# 0 ce92b” 让rgb2hex = c = > ' # ' + c.match (\ d + / g) . map (x = > (+ x) .toString (16) .padStart (2,0)) . join ' ' console.log (rgb2hex(“rgb(12233年,43”);

和@Jim F答案一样，但是使用ES6语法，所以指令更少:

const rgb2hex = (rgb) => {
  if (rgb.search("rgb") === -1) return rgb;
  rgb = rgb.match(/^rgba?\((\d+),\s*(\d+),\s*(\d+)(?:,\s*(\d+))?\)$/);
  const hex = (x) => ("0" + parseInt(x).toString(16)).slice(-2);
  return "#" + hex(rgb[1]) + hex(rgb[2]) + hex(rgb[3]);
};

var hexDigits = new Array
        ("0","1","2","3","4","5","6","7","8","9","a","b","c","d","e","f"); 

//Function to convert rgb color to hex format
function rgb2hex(rgb) {
 rgb = rgb.match(/^rgb\((\d+),\s*(\d+),\s*(\d+)\)$/);
 return "#" + hex(rgb[1]) + hex(rgb[2]) + hex(rgb[3]);
}

function hex(x) {
  return isNaN(x) ? "00" : hexDigits[(x - x % 16) / 16] + hexDigits[x % 16];
 }

(源)