UISegmentedControl.appearance().setTitleTextAttributes(NSDictionary(objects: [UIFont.systemFont(ofSize: 16.0)],
                                                                        forKeys: [kCTFontAttributeName as! NSCopying]) as? [AnyHashable : Any],
                                                           for: UIControlState.normal)

// Set font-size and font-femily the way you want
UIFont *objFont = [UIFont fontWithName:@"DroidSans" size:18.0f];

// Add font object to Dictionary
NSDictionary *dictAttributes = [NSDictionary dictionaryWithObject:objFont forKey:NSFontAttributeName];

// Set dictionary to the titleTextAttributes
[yourSegment setTitleTextAttributes:dictAttributes forState:UIControlStateNormal];

如果您有任何疑问，请联系我。

在iOS 5.0+中使用Appearance API:

[[UISegmentedControl appearance] setTitleTextAttributes:[NSDictionary dictionaryWithObjectsAndKeys:[UIFont fontWithName:@"STHeitiSC-Medium" size:13.0], UITextAttributeFont, nil] forState:UIControlStateNormal];

链接: http://developer.apple.com/library/ios/#documentation/UIKit/Reference/UIAppearance_Protocol/Reference/Reference.html#//apple_ref/doc/uid/TP40010906

http://www.raywenderlich.com/4344/user-interface-customization-in-ios-5

XCode 8.1, Swift 3

import UIKit
class ViewController: UIViewController {
    override func viewDidLoad() {
        super.viewDidLoad()
        UISegmentedControl.appearance().setTitleTextAttributes(NSDictionary(objects: [UIFont.systemFont(ofSize: 24.0)], 
        forKeys: [NSFontAttributeName as NSCopying]) as? [AnyHashable : Any], 
        for: UIControlState.normal)
    }
}

只需要改变数值(ofSize: 24.0)

C# / Xamarin：

segment.SetTitleTextAttributes(new UITextAttributes { 
    Font = UIFont.SystemFontOfSize(font_size) }, UIControlState.Normal);

在swift 5中，

let font = UIFont.systemFont(ofSize: 16)
UISegmentedControl.appearance().setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)