在swift 5中，

let font = UIFont.systemFont(ofSize: 16)
UISegmentedControl.appearance().setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)

XCode 8.1, Swift 3

import UIKit
class ViewController: UIViewController {
    override func viewDidLoad() {
        super.viewDidLoad()
        UISegmentedControl.appearance().setTitleTextAttributes(NSDictionary(objects: [UIFont.systemFont(ofSize: 24.0)], 
        forKeys: [NSFontAttributeName as NSCopying]) as? [AnyHashable : Any], 
        for: UIControlState.normal)
    }
}

只需要改变数值(ofSize: 24.0)

你可以通过递归检查从UISegmentedControl开始的每个视图来获得UILabel的实际字体。我不知道这是不是最好的方法，但它确实有效。

@interface tmpSegmentedControlTextViewController : UIViewController {
}

@property (nonatomic, assign) IBOutlet UISegmentedControl * theControl;

@end

@implementation tmpSegmentedControlTextViewController

@synthesize theControl; // UISegmentedControl

- (void)viewDidLoad {
  [self printControl:[self theControl]];
  [super viewDidLoad];
}

- (void) printControl:(UIView *) view {
  NSArray * views = [view subviews];
  NSInteger idx,idxMax;
  for (idx = 0, idxMax = views.count; idx < idxMax; idx++) {
    UIView * thisView = [views objectAtIndex:idx];
    UILabel * tmpLabel = (UILabel *) thisView;
    if ([tmpLabel respondsToSelector:@selector(text)]) {
      NSLog(@"TEXT for view %d: %@",idx,tmpLabel.text);
      [tmpLabel setTextColor:[UIColor blackColor]];
    }

    if (thisView.subviews.count) {
      NSLog(@"View has subviews");
      [self printControl:thisView];
    }
  }
}

@end

在上面的代码中，我只是设置了UILabel的文本颜色，但你也可以获取或设置字体属性。

在swift 5中，

let font = UIFont.systemFont(ofSize: 16)
UISegmentedControl.appearance().setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)

这里我已经更新了iOS8

[[UISegmentedControl appearance] setTitleTextAttributes:[NSDictionary dictionaryWithObjectsAndKeys:[UIFont fontWithName:@"STHeitiSC-Medium" size:13.0], NSFontAttributeName, nil] forState:UIControlStateNormal];

我也遇到了同样的问题。这段代码为整个分段控件设置字体大小。类似的方法也可以用于设置字体类型。注意，这只适用于iOS5+

Obj C:

UIFont *font = [UIFont boldSystemFontOfSize:12.0f];
NSDictionary *attributes = [NSDictionary dictionaryWithObject:font
                                                       forKey:NSFontAttributeName];
[segmentedControl setTitleTextAttributes:attributes 
                                forState:UIControlStateNormal];

编辑:UITextAttributeFont已弃用-使用NSFontAttributeName代替。

编辑#2:对于Swift 4 NSFontAttributeName已更改为NSAttributedStringKey.font。

斯威夫特5:

let font = UIFont.systemFont(ofSize: 16)
segmentedControl.setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)

斯威夫特4:

let font = UIFont.systemFont(ofSize: 16)
segmentedControl.setTitleTextAttributes([NSAttributedStringKey.font: font],
                                        for: .normal)

斯威夫特3:

let font = UIFont.systemFont(ofSize: 16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font],
                                        for: .normal)

斯威夫特2.2:

let font = UIFont.systemFontOfSize(16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font], 
    forState: UIControlState.Normal)

多亏了@audrey-gordeev的Swift实现