我知道这个话题很老了，但如果有人还需要正确答案，你需要什么:

Override standard flow layout. Add implementation like that: - (NSArray *) layoutAttributesForElementsInRect:(CGRect)rect { NSArray *answer = [super layoutAttributesForElementsInRect:rect]; for(int i = 1; i < [answer count]; ++i) { UICollectionViewLayoutAttributes *currentLayoutAttributes = answer[i]; UICollectionViewLayoutAttributes *prevLayoutAttributes = answer[i - 1]; NSInteger maximumSpacing = 4; NSInteger origin = CGRectGetMaxX(prevLayoutAttributes.frame); if(origin + maximumSpacing + currentLayoutAttributes.frame.size.width < self.collectionViewContentSize.width) { CGRect frame = currentLayoutAttributes.frame; frame.origin.x = origin + maximumSpacing; currentLayoutAttributes.frame = frame; } } return answer; }

其中maximumSpacing可以设置为您喜欢的任何值。这个技巧保证了单元格之间的空间将等于maximumSpacing!!

请注意属性名minimumInterItemSpacing。这将是项目之间的最小间距，而不是精确的间距。如果你设置minimumInterItemSpacing为某个值，你可以确保spacing不会小于该值。但有机会获得更高的价值。

实际上，项目之间的间距取决于几个因素itemSize和sectionInset。集合视图根据这些值动态放置内容。所以你不能保证精确的间距。你应该用sectionInset和minimumInterItemSpacing做一些试错。

我发现了使用IB配置单元格或行之间的间距的非常简单的方法。

只需从storyboard/Xib文件中选择UICollectionView，然后按下图所示单击大小检查器。

要以编程方式配置空间，请使用以下属性。

1)用于设置行间距。

[self.collectionView setMinimumLineSpacing:5];

2)用于设置项目/单元格之间的间距。

[self.collectionView setMinimumInteritemSpacing:5];

投票的答案(以及快速版本)有一个小问题:右边会有一个很大的空格。

这是因为流布局是定制的，以使单元格间距精确，具有浮动左行为。

我的解决方案是操纵部分插入，使部分是对齐中心，但间距是完全指定的。

在下面的截图中，项目/行间距正好是8pt，而左右插入部分将大于8pt(使其居中对齐):

这样的Swift代码:

private let minItemSpacing: CGFloat = 8
private let itemWidth: CGFloat      = 100
private let headerHeight: CGFloat   = 32

override func viewDidLayoutSubviews() {
    super.viewDidLayoutSubviews()

    // Create our custom flow layout that evenly space out the items, and have them in the center
    let layout = UICollectionViewFlowLayout()
    layout.itemSize = CGSize(width: itemWidth, height: itemWidth)
    layout.minimumInteritemSpacing = minItemSpacing
    layout.minimumLineSpacing = minItemSpacing
    layout.headerReferenceSize = CGSize(width: 0, height: headerHeight)

    // Find n, where n is the number of item that can fit into the collection view
    var n: CGFloat = 1
    let containerWidth = collectionView.bounds.width
    while true {
        let nextN = n + 1
        let totalWidth = (nextN*itemWidth) + (nextN-1)*minItemSpacing
        if totalWidth > containerWidth {
            break
        } else {
            n = nextN
        }
    }

    // Calculate the section inset for left and right. 
    // Setting this section inset will manipulate the items such that they will all be aligned horizontally center.
    let inset = max(minItemSpacing, floor( (containerWidth - (n*itemWidth) - (n-1)*minItemSpacing) / 2 ) )
    layout.sectionInset = UIEdgeInsets(top: minItemSpacing, left: inset, bottom: minItemSpacing, right: inset)

    collectionView.collectionViewLayout = layout
}

以前的版本并没有真正工作的部分> 1。所以我的解决方案在这里找到了https://codentrick.com/create-a-tag-flow-layout-with-uicollectionview/。对于懒惰的人:

override func layoutAttributesForElements(in rect: CGRect) -> [UICollectionViewLayoutAttributes]? {
    let attributesForElementsInRect = super.layoutAttributesForElements(in: rect)
    var newAttributesForElementsInRect = [UICollectionViewLayoutAttributes]()
    // use a value to keep track of left margin
    var leftMargin: CGFloat = 0.0;
    for attributes in attributesForElementsInRect! {
        let refAttributes = attributes 
        // assign value if next row
        if (refAttributes.frame.origin.x == self.sectionInset.left) {
            leftMargin = self.sectionInset.left
        } else {
            // set x position of attributes to current margin
            var newLeftAlignedFrame = refAttributes.frame
            newLeftAlignedFrame.origin.x = leftMargin
            refAttributes.frame = newLeftAlignedFrame
        }
        // calculate new value for current margin
        leftMargin += refAttributes.frame.size.width + 10
        newAttributesForElementsInRect.append(refAttributes)
    }

    return newAttributesForElementsInRect
}

我在Swift 3单元格间距的解决方案，如Instagram:

lazy var collectionView: UICollectionView = {
    let layout = UICollectionViewFlowLayout()
    let cv = UICollectionView(frame: .zero, collectionViewLayout: layout)
    cv.backgroundColor = UIColor.rgb(red: 227, green: 227, blue: 227)
    cv.showsVerticalScrollIndicator = false
    layout.scrollDirection = .vertical
    layout.minimumLineSpacing = 1
    layout.minimumInteritemSpacing = 1
    return cv
}()

func collectionView(_ collectionView: UICollectionView, layout collectionViewLayout: UICollectionViewLayout, sizeForItemAt indexPath: IndexPath) -> CGSize {

    switch UIDevice.current.modelName {
    case "iPhone 4":
        return CGSize(width: 106, height: 106)
    case "iPhone 5":
        return CGSize(width: 106, height: 106)
    case "iPhone 6,7":
        return CGSize(width: 124, height: 124)
    case "iPhone Plus":
        return CGSize(width: 137, height: 137)
    default:
        return CGSize(width: frame.width / 3, height: frame.width / 3)
    }
}

如何编程检测设备: https://stackoverflow.com/a/26962452/6013170