一个简单的选项，通过先反转字符串和基本正则表达式来正确放置逗号。

String.prototype.reverse = function() {
    return this.split('').reverse().join('');
};

Number.prototype.toCurrency = function( round_decimal /*boolean*/ ) {       
     // format decimal or round to nearest integer
     var n = this.toFixed( round_decimal ? 0 : 2 );

     // convert to a string, add commas every 3 digits from left to right 
     // by reversing string
     return (n + '').reverse().replace( /(\d{3})(?=\d)/g, '$1,' ).reverse();
};

处理货币输出（包括负数）的函数。样本输出：$5.23-$5.23

function formatCurrency(total) {
    var neg = false;
    if(total < 0) {
        neg = true;
        total = Math.abs(total);
    }
    return (neg ? "-$" : '$') + parseFloat(total, 10).toFixed(2).replace(/(\d)(?=(\d{3})+\.)/g, "$1,").toString();
}

String.prototype.toPrice = function () {
    var v;
    if (/^\d+(,\d+)$/.test(this))
        v = this.replace(/,/, '.');
    else if (/^\d+((,\d{3})*(\.\d+)?)?$/.test(this))
        v = this.replace(/,/g, "");
    else if (/^\d+((.\d{3})*(,\d+)?)?$/.test(this))
        v = this.replace(/\./g, "").replace(/,/, ".");
    var x = parseFloat(v).toFixed(2).toString().split("."),
    x1 = x[0],
    x2 = ((x.length == 2) ? "." + x[1] : ".00"),
    exp = /^([0-9]+)(\d{3})/;
    while (exp.test(x1))
        x1 = x1.replace(exp, "$1" + "," + "$2");
    return x1 + x2;
}

alert("123123".toPrice()); //123,123.00
alert("123123,316".toPrice()); //123,123.32
alert("12,312,313.33213".toPrice()); //12,312,313.33
alert("123.312.321,32132".toPrice()); //123,312,321.32

一种仅满足原始要求的极简方法：

function formatMoney(n) {
    return "$ " + (Math.round(n * 100) / 100).toLocaleString();
}

@丹尼尔·马格廖拉：你说得对。以上是一个仓促而不完整的实施。以下是正确的实施方式：

function formatMoney(n) {
    return "$ " + n.toLocaleString().split(".")[0] + "."
        + n.toFixed(2).split(".")[1];
}

http://code.google.com/p/javascript-number-formatter/:

短、快、灵活但独立。只有75行，包括MIT许可证信息、空白行和注释。接受标准数字格式，如#、##0.00或带否定的-000.####。接受任何国家/地区格式，如###0,00，#，###.##，#‘###.##或任何类型的非编号符号。接受任意数字分组。#、##、#0.000或#、####0.##均有效。接受任何冗余/防傻瓜格式。##、###、##。#或0#、#00####0#都正常。自动数字舍入。简单的界面，只需提供如下掩码和值：格式（“0.0000”，3.141592）

UPDATE这是我自己开发的应用程序，用于最常见的任务：

var NumUtil = {};

/**
  Petty print 'num' wth exactly 'signif' digits.
  pp(123.45, 2) == "120"
  pp(0.012343, 3) == "0.0123"
  pp(1.2, 3) == "1.20"
*/
NumUtil.pp = function(num, signif) {
    if (typeof(num) !== "number")
        throw 'NumUtil.pp: num is not a number!';
    if (isNaN(num))
        throw 'NumUtil.pp: num is NaN!';
    if (num < 1e-15 || num > 1e15)
        return num;
    var r = Math.log(num)/Math.LN10;
    var dot = Math.floor(r) - (signif-1);
    r = r - Math.floor(r) + (signif-1);
    r = Math.round(Math.exp(r * Math.LN10)).toString();
    if (dot >= 0) {
        for (; dot > 0; dot -= 1)
            r += "0";
        return r;
    } else if (-dot >= r.length) {
        var p = "0.";
        for (; -dot > r.length; dot += 1) {
            p += "0";
        }
        return p+r;
    } else {
        return r.substring(0, r.length + dot) + "." + r.substring(r.length + dot);
    }
}

/** Append leading zeros up to 2 digits. */
NumUtil.align2 = function(v) {
    if (v < 10)
        return "0"+v;
    return ""+v;
}
/** Append leading zeros up to 3 digits. */
NumUtil.align3 = function(v) {
    if (v < 10)
        return "00"+v;
    else if (v < 100)
        return "0"+v;
    return ""+v;
}

NumUtil.integer = {};

/** Round to integer and group by 3 digits. */
NumUtil.integer.pp = function(num) {
    if (typeof(num) !== "number") {
        console.log("%s", new Error().stack);
        throw 'NumUtil.integer.pp: num is not a number!';
    }
    if (isNaN(num))
        throw 'NumUtil.integer.pp: num is NaN!';
    if (num > 1e15)
        return num;
    if (num < 0)
        throw 'Negative num!';
    num = Math.round(num);
    var group = num % 1000;
    var integ = Math.floor(num / 1000);
    if (integ === 0) {
        return group;
    }
    num = NumUtil.align3(group);
    while (true) {
        group = integ % 1000;
        integ = Math.floor(integ / 1000);
        if (integ === 0)
            return group + " " + num;
        num = NumUtil.align3(group) + " " + num;
    }
    return num;
}

NumUtil.currency = {};

/** Round to coins and group by 3 digits. */
NumUtil.currency.pp = function(amount) {
    if (typeof(amount) !== "number")
        throw 'NumUtil.currency.pp: amount is not a number!';
    if (isNaN(amount))
        throw 'NumUtil.currency.pp: amount is NaN!';
    if (amount > 1e15)
        return amount;
    if (amount < 0)
        throw 'Negative amount!';
    if (amount < 1e-2)
        return 0;
    var v = Math.round(amount*100);
    var integ = Math.floor(v / 100);
    var frac = NumUtil.align2(v % 100);
    var group = integ % 1000;
    integ = Math.floor(integ / 1000);
    if (integ === 0) {
        return group + "." + frac;
    }
    amount = NumUtil.align3(group);
    while (true) {
        group = integ % 1000;
        integ = Math.floor(integ / 1000);
        if (integ === 0)
            return group + " " + amount + "." + frac;
        amount = NumUtil.align3(group) + " " + amount;
    }
    return amount;
}

+1向Jonathan M提供原始方法。由于这是一个明确的货币格式化程序，我继续在输出中添加了货币符号（默认为“$”），并添加了一个默认逗号作为千位分隔符。如果您实际上不需要货币符号（或千位分隔符），只需使用“”（空字符串）作为它的参数。

Number.prototype.formatMoney = function(decPlaces, thouSeparator, decSeparator, currencySymbol) {
    // check the args and supply defaults:
    decPlaces = isNaN(decPlaces = Math.abs(decPlaces)) ? 2 : decPlaces;
    decSeparator = decSeparator == undefined ? "." : decSeparator;
    thouSeparator = thouSeparator == undefined ? "," : thouSeparator;
    currencySymbol = currencySymbol == undefined ? "$" : currencySymbol;

    var n = this,
        sign = n < 0 ? "-" : "",
        i = parseInt(n = Math.abs(+n || 0).toFixed(decPlaces)) + "",
        j = (j = i.length) > 3 ? j % 3 : 0;

    return sign + currencySymbol + (j ? i.substr(0, j) + thouSeparator : "") + i.substr(j).replace(/(\d{3})(?=\d)/g, "$1" + thouSeparator) + (decPlaces ? decSeparator + Math.abs(n - i).toFixed(decPlaces).slice(2) : "");
};