一个简单的选项，通过先反转字符串和基本正则表达式来正确放置逗号。

String.prototype.reverse = function() {
    return this.split('').reverse().join('');
};

Number.prototype.toCurrency = function( round_decimal /*boolean*/ ) {       
     // format decimal or round to nearest integer
     var n = this.toFixed( round_decimal ? 0 : 2 );

     // convert to a string, add commas every 3 digits from left to right 
     // by reversing string
     return (n + '').reverse().replace( /(\d{3})(?=\d)/g, '$1,' ).reverse();
};

Intl.NumberFormat（国际数字格式）

var number = 3500;
alert(new Intl.NumberFormat().format(number));
// → "3,500" if in US English locale

或者JavaScript中的PHP的number_format。

这是我的。。。

function thousandCommas(num) {
  num = num.toString().split('.');
  var ints = num[0].split('').reverse();
  for (var out=[],len=ints.length,i=0; i < len; i++) {
    if (i > 0 && (i % 3) === 0) out.push(',');
    out.push(ints[i]);
  }
  out = out.reverse() && out.join('');
  if (num.length === 2) out += '.' + num[1];
  return out;
}

Patrick热门答案的CoffeeScript：

Number::formatMoney = (decimalPlaces, decimalChar, thousandsChar) ->
  n = this
  c = decimalPlaces
  d = decimalChar
  t = thousandsChar
  c = (if isNaN(c = Math.abs(c)) then 2 else c)
  d = (if d is undefined then "." else d)
  t = (if t is undefined then "," else t)
  s = (if n < 0 then "-" else "")
  i = parseInt(n = Math.abs(+n or 0).toFixed(c)) + ""
  j = (if (j = i.length) > 3 then j % 3 else 0)
  s + (if j then i.substr(0, j) + t else "") + i.substr(j).replace(/(\d{3})(?=\d)/g, "$1" + t) + (if c then d + Math.abs(n - i).toFixed(c).slice(2) else "")

我建议使用Google可视化API中的NumberFormat类。

你可以这样做：

var formatter = new google.visualization.NumberFormat({
    prefix: '$',
    pattern: '#,###,###.##'
});

formatter.formatValue(1000000); // $ 1,000,000

http://code.google.com/p/javascript-number-formatter/:

短、快、灵活但独立。只有75行，包括MIT许可证信息、空白行和注释。接受标准数字格式，如#、##0.00或带否定的-000.####。接受任何国家/地区格式，如###0,00，#，###.##，#‘###.##或任何类型的非编号符号。接受任意数字分组。#、##、#0.000或#、####0.##均有效。接受任何冗余/防傻瓜格式。##、###、##。#或0#、#00####0#都正常。自动数字舍入。简单的界面，只需提供如下掩码和值：格式（“0.0000”，3.141592）

UPDATE这是我自己开发的应用程序，用于最常见的任务：

var NumUtil = {};

/**
  Petty print 'num' wth exactly 'signif' digits.
  pp(123.45, 2) == "120"
  pp(0.012343, 3) == "0.0123"
  pp(1.2, 3) == "1.20"
*/
NumUtil.pp = function(num, signif) {
    if (typeof(num) !== "number")
        throw 'NumUtil.pp: num is not a number!';
    if (isNaN(num))
        throw 'NumUtil.pp: num is NaN!';
    if (num < 1e-15 || num > 1e15)
        return num;
    var r = Math.log(num)/Math.LN10;
    var dot = Math.floor(r) - (signif-1);
    r = r - Math.floor(r) + (signif-1);
    r = Math.round(Math.exp(r * Math.LN10)).toString();
    if (dot >= 0) {
        for (; dot > 0; dot -= 1)
            r += "0";
        return r;
    } else if (-dot >= r.length) {
        var p = "0.";
        for (; -dot > r.length; dot += 1) {
            p += "0";
        }
        return p+r;
    } else {
        return r.substring(0, r.length + dot) + "." + r.substring(r.length + dot);
    }
}

/** Append leading zeros up to 2 digits. */
NumUtil.align2 = function(v) {
    if (v < 10)
        return "0"+v;
    return ""+v;
}
/** Append leading zeros up to 3 digits. */
NumUtil.align3 = function(v) {
    if (v < 10)
        return "00"+v;
    else if (v < 100)
        return "0"+v;
    return ""+v;
}

NumUtil.integer = {};

/** Round to integer and group by 3 digits. */
NumUtil.integer.pp = function(num) {
    if (typeof(num) !== "number") {
        console.log("%s", new Error().stack);
        throw 'NumUtil.integer.pp: num is not a number!';
    }
    if (isNaN(num))
        throw 'NumUtil.integer.pp: num is NaN!';
    if (num > 1e15)
        return num;
    if (num < 0)
        throw 'Negative num!';
    num = Math.round(num);
    var group = num % 1000;
    var integ = Math.floor(num / 1000);
    if (integ === 0) {
        return group;
    }
    num = NumUtil.align3(group);
    while (true) {
        group = integ % 1000;
        integ = Math.floor(integ / 1000);
        if (integ === 0)
            return group + " " + num;
        num = NumUtil.align3(group) + " " + num;
    }
    return num;
}

NumUtil.currency = {};

/** Round to coins and group by 3 digits. */
NumUtil.currency.pp = function(amount) {
    if (typeof(amount) !== "number")
        throw 'NumUtil.currency.pp: amount is not a number!';
    if (isNaN(amount))
        throw 'NumUtil.currency.pp: amount is NaN!';
    if (amount > 1e15)
        return amount;
    if (amount < 0)
        throw 'Negative amount!';
    if (amount < 1e-2)
        return 0;
    var v = Math.round(amount*100);
    var integ = Math.floor(v / 100);
    var frac = NumUtil.align2(v % 100);
    var group = integ % 1000;
    integ = Math.floor(integ / 1000);
    if (integ === 0) {
        return group + "." + frac;
    }
    amount = NumUtil.align3(group);
    while (true) {
        group = integ % 1000;
        integ = Math.floor(integ / 1000);
        if (integ === 0)
            return group + " " + amount + "." + frac;
        amount = NumUtil.align3(group) + " " + amount;
    }
    return amount;
}