你可以把一个中间件放在最后一个位置，它会抛出一个NotFound错误， 甚至直接渲染404页面:

app.use(function(req,res){
    res.status(404).render('404.jade');
});

你问题的答案是:

app.use(function(req, res) {
    res.status(404).end('error');
});

有一篇很棒的文章讲述了为什么这是最好的方法。

我认为你应该首先定义你所有的路线，然后作为最后的路线添加

//The 404 Route (ALWAYS Keep this as the last route)
app.get('*', function(req, res){
  res.status(404).send('what???');
});

一个示例应用程序的工作:

app.js:

var express = require('express'),
    app = express.createServer();

app.use(express.static(__dirname + '/public'));

app.get('/', function(req, res){
  res.send('hello world');
});

//The 404 Route (ALWAYS Keep this as the last route)
app.get('*', function(req, res){
  res.send('what???', 404);
});

app.listen(3000, '127.0.0.1');

alfred@alfred-laptop:~/node/stackoverflow/6528876$ mkdir public
alfred@alfred-laptop:~/node/stackoverflow/6528876$ find .
alfred@alfred-laptop:~/node/stackoverflow/6528876$ echo "I don't find a function for that... Anyone knows?" > public/README.txt
alfred@alfred-laptop:~/node/stackoverflow/6528876$ cat public/README.txt 

.
./app.js
./public
./public/README.txt

alfred@alfred-laptop:~/node/stackoverflow/6528876$ curl http://localhost:3000/
hello world
alfred@alfred-laptop:~/node/stackoverflow/6528876$ curl http://localhost:3000/README.txt
I don't find a function for that... Anyone knows?

发送到自定义页面:

app.get('*', function(req, res){
  if (req.accepts('html')) {
     res.send('404', '<script>location.href = "/the-404-page.html";</script>');
     return;
  }
});

https://github.com/robrighter/node-boilerplate/blob/master/templates/app/server.js

这就是node-boilerplate所做的。

嗨，请找到答案

const express = require('express');
const app = express();
const port = 8080;

app.get('/', (req, res) => res.send('Hello home!'));
app.get('/about-us', (req, res) => res.send('Hello about us!'));
app.post('/user/set-profile', (req, res) => res.send('Hello profile!'));
//last 404 page 
app.get('*', (req, res) => res.send('Page Not found 404'));
app.listen(port, () => console.log(`Example app listening on port ${port}!`));