Syncfusion Essential XlsIO可以做到这一点。它对Microsoft office没有依赖性，并且对不同的平台也有特定的支持。

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代码示例：

//Creates a new instance for ExcelEngine.
ExcelEngine excelEngine = new ExcelEngine();
//Loads or open an existing workbook through Open method of IWorkbooks
IWorkbook workbook = excelEngine.Excel.Workbooks.Open(fileName);
//To-Do some manipulation|
//To-Do some manipulation
//Set the version of the workbook.
workbook.Version = ExcelVersion.Excel2013;
//Save the workbook in file system as xlsx format
workbook.SaveAs(outputFileName);

如果您符合资格（收入低于100万美元），可通过社区许可计划免费获得整套控件。注：我为Syncfusion工作。

我使用了几个选项：

如果XLSX是必须的：ExcelPackage是一个很好的开始，但当开发人员停止工作时就夭折了。ExML不是一个坏选项，我仍在一些生产网站上使用它。

不过，对于我的所有新项目，我都使用NPOI，即Apache POI的.NET端口。NPOI 2.0（Alpha）也支持XLSX。

我成功地使用了以下开源项目：

用于OOXML格式的ExcelPackage（Office 2007）XLS格式的NPOI（Office 2003）。NPOI 2.0（Beta版）也支持XLSX。

看看我的博客帖子：

在C中创建Excel电子表格.XLS和.XLSX#

带有Excel表格和动态图表的NPOI

在我的项目中，我使用一些.net库来提取Excel文件（.xls和.xlsx）

为了导出数据，我经常使用rdlc。

要修改我使用的excel文件（尝试设置空白单元格A15时的示例代码）：

关闭的XML

        //Closed XML
        var workbook = new XLWorkbook(sUrlFile); // load the existing excel file
        var worksheet = workbook.Worksheets.Worksheet(1);
        worksheet.Cell("A15").SetValue("");
        workbook.Save();

铁杆XL

       string sUrlFile = "G:\\ReportAmortizedDetail.xls";
        WorkBook workbook = WorkBook.Load(sUrlFile);
        WorkSheet sheet = workbook.WorkSheets.First();
        //Select cells easily in Excel notation and return the calculated value
        sheet["A15"].First().Value = "";
        sheet["A15"].First().FormatString = "";

        workbook.Save();
        workbook.Close();
        workbook = null;

SpireXLS（当我尝试时，库会打印附加页，以提供我们使用试用库的信息

            string sUrlFile = "G:\\ReportAmortizedDetail.xls";
            Workbook workbook = new Workbook();
            workbook.LoadFromFile(sUrlFile);
            //Get the 1st sheet
            Worksheet sheet = workbook.Worksheets[0];
            //Specify the cell range
            CellRange range = sheet.Range["A15"];
            //Find all matched text in the range
            CellRange[] cells = range.FindAllString("hi", false, false);
            //Replace text
            foreach (CellRange cell in range)
            {
                cell.Text = "";
            }
            //Save
            workbook.Save();

Jet Oledb公司

    //ExcelTool Class
    public static int ExcelUpdateSheets(string path, string sWorksheetName, string sCellLocation, string sValue)
    {
        int iResult = -99;
        String sConnectionString = @"Provider=Microsoft.Jet.OLEDB.4.0;Data Source=" + path + ";Extended Properties='Excel 8.0;HDR=NO'";
        OleDbConnection objConn = new OleDbConnection(sConnectionString);
        objConn.Open();
        OleDbCommand objCmdSelect = new OleDbCommand("UPDATE [" + sWorksheetName + "$" + sCellLocation + "] SET F1=" + UtilityClass.ValueSQL(sValue), objConn);
        objCmdSelect.ExecuteNonQuery();
        objConn.Close();

        return iResult;
    }

用法：

    ExcelTool.ExcelUpdateSheets(sUrlFile, "ReportAmortizedDetail", "A15:A15", "");

天冬氨酸

            var workbook = new Aspose.Cells.Workbook(sUrlFile);
            // access first (default) worksheet
            var sheet = workbook.Worksheets[0];
            // access CellsCollection of first worksheet
            var cells = sheet.Cells;
            // write HelloWorld to cells A1
            cells["A15"].Value = "";
            // save spreadsheet to disc
            workbook.Save(sUrlFile);
            workbook.Dispose();
            workbook = null;

您可以使用此库创建格式良好的Excel文件：http://officehelper.codeplex.com/documentation参见以下示例：

using (ExcelHelper helper = new ExcelHelper(TEMPLATE_FILE_NAME, GENERATED_FILE_NAME))
{
    helper.Direction = ExcelHelper.DirectionType.TOP_TO_DOWN;
    helper.CurrentSheetName = "Sheet1";
    helper.CurrentPosition = new CellRef("C3");

    //the template xlsx should contains the named range "header"; use the command "insert"/"name".
    helper.InsertRange("header");

    //the template xlsx should contains the named range "sample1";
    //inside this range you should have cells with these values:
    //<name> , <value> and <comment>, which will be replaced by the values from the getSample()
    CellRangeTemplate sample1 = helper.CreateCellRangeTemplate("sample1", new List<string> {"name", "value", "comment"}); 
    helper.InsertRange(sample1, getSample());

    //you could use here other named ranges to insert new cells and call InsertRange as many times you want, 
    //it will be copied one after another;
    //even you can change direction or the current cell/sheet before you insert

    //typically you put all your "template ranges" (the names) on the same sheet and then you just delete it
    helper.DeleteSheet("Sheet3");
}        

示例如下：

private IEnumerable<List<object>> getSample()
{
    var random = new Random();

    for (int loop = 0; loop < 3000; loop++)
    {
        yield return new List<object> {"test", DateTime.Now.AddDays(random.NextDouble()*100 - 50), loop};
    }
}

您可以使用OLEDB创建和操作Excel文件。选中此项：使用OLEDB读写Excel。

典型示例：

using (OleDbConnection conn = new OleDbConnection("Provider=Microsoft.Jet.OLEDB.4.0;Data Source=C:\\temp\\test.xls;Extended Properties='Excel 8.0;HDR=Yes'"))
{
  conn.Open();
  OleDbCommand cmd = new OleDbCommand("CREATE TABLE [Sheet1] ([Column1] string, [Column2] string)", conn);
  cmd.ExecuteNonQuery();
}

编辑-更多链接：

嘿，脚本人！如何在不使用Excel的情况下从Excel读取？如何使用ADO.NET在Visual Basic.NET中检索和修改Excel工作簿中的记录使用ADO.NET C#DbProviderFactory读写Excel电子表格