我个人认为，以下是用Python编写原始SQL查询的最佳（简单、安全和Python化）方法，尤其是在使用Python的sqlite3模块时：

query = '''
    SELECT
        action.descr as action,
        role.id as role_id,
        role.descr as role
    FROM
        public.role_action_def,
        public.role,
        public.record_def,
        public.action
    WHERE
        role.id = role_action_def.role_id
        AND record_def.id = role_action_def.def_id
        AND action.id = role_action_def.action_id
        AND role_action_def.account_id = ?
        AND record_def.account_id = ?
        AND def_id = ?
'''
vars = (account_id, account_id, def_id)   # a tuple of query variables
cursor.execute(query, vars)   # using Python's sqlite3 module

Pros

整洁而简单的代码（Pythonic！）避免SQL注入与Python 2和Python 3兼容（毕竟是Pythonic）不需要字符串串联无需确保每行最右边的字符是空格

Cons

由于查询中的变量被替换为？占位符，它可能会变得有点难以跟踪哪个？当查询中有很多Python变量时，将由哪个Python变量替换。

“la”Scala方式（但我认为这是OP要求的最具Python风格的方式）：

description = """
            | The intention of this module is to provide a method to
            | pass meta information in markdown_ header files for
            | using it in jinja_ templates.
            |
            | Also, to provide a method to use markdown files as jinja
            | templates. Maybe you prefer to see the code than
            | to install it.""".replace('\n            | \n','\n').replace('            | ',' ')

如果您希望最后的str没有跳转行，只需将\n放在第二个替换的第一个参数的开头：

.replace('\n            | ',' ')`.

注意：“…templates.”和“另外，…”之间的白线需要在|后面加一个空格。

结合以下观点：

Levon或Jesse、Faheel和ddrscott

根据我的格式建议，您可以将查询写成：

query = ('SELECT'
             ' action.descr as "action"'
             ',role.id as role_id'
             ',role.descr as role'
         ' FROM'
             ' public.role_action_def'
             ',public.role'
             ',public.record_def'
             ',public.action'
         ' WHERE'
             ' role.id = role_action_def.role_id'
             ' AND'
             ' record_def.id = role_action_def.def_id'
             ' AND'
             ' action.id = role_action_def.action_id'
             ' AND'
             ' role_action_def.account_id = ?' # account_id
             ' AND'
             ' record_def.account_id = ?'      # account_id
             ' AND'
             ' def_id = ?'                     # def_id
         )

 vars = (account_id, account_id, def_id)     # A tuple of the query variables
 cursor.execute(query, vars)                 # Using Python's sqlite3 module

或类似：

vars = []
query = ('SELECT'
             ' action.descr as "action"'
             ',role.id as role_id'
             ',role.descr as role'
         ' FROM'
             ' public.role_action_def'
             ',public.role'
             ',public.record_def'
             ',public.action'
         ' WHERE'
             ' role.id = role_action_def.role_id'
             ' AND'
             ' record_def.id = role_action_def.def_id'
             ' AND'
             ' action.id = role_action_def.action_id'
             ' AND'
             ' role_action_def.account_id = '
                 vars.append(account_id) or '?'
             ' AND'
             ' record_def.account_id = '
                 vars.append(account_id) or '?'
             ' AND'
             ' def_id = '
                 vars.append(def_id) or '?'
         )

 cursor.execute(query, tuple(vars))  # Using Python's sqlite3 module

与“IN”和“vars.extend（options）”或“n_options（len（option））”一起使用可能很有趣，其中：

def n_options(count):
    return '(' + ','.join(count*'?') + ')'

或者从darkcaline那里得到的提示是，您可能仍然会在使用前导空格和分隔符以及命名占位符时出错：

SPACE_SEP = ' '
COMMA_SEP = ', '
AND_SEP   = ' AND '

query = SPACE_SEP.join((
    'SELECT',
        COMMA_SEP.join((
        'action.descr as "action"',
        'role.id as role_id',
        'role.descr as role',
        )),
    'FROM',
        COMMA_SEP.join((
        'public.role_action_def',
        'public.role',
        'public.record_def',
        'public.action',
        )),
    'WHERE',
        AND_SEP.join((
        'role.id = role_action_def.role_id',
        'record_def.id = role_action_def.def_id',
        'action.id = role_action_def.action_id',
        'role_action_def.account_id = :account_id',
        'record_def.account_id = :account_id',
        'def_id = :def_id',
        )),
    ))

vars = {'account_id':account_id,'def_id':def_id}  # A dictionary of the query variables
cursor.execute(query, vars)                       # Using Python's sqlite3 module

请参阅Cursor.execute-function的文档。

“这是[最Python]的方式！”-。。。

其他人已经提到了圆括号方法，但我想补充一点，使用圆括号时，允许内联注释。

对每个片段的注释：

nursery_rhyme = (
    'Mary had a little lamb,'          # Comments are great!
    'its fleece was white as snow.'
    'And everywhere that Mary went,'
    'her sheep would surely go.'       # What a pesky sheep.
)

继续后不允许注释：

使用反斜杠行延续符（\）时，不允许使用注释。您将收到一个SyntaxError：一行接一行的连续字符错误。

nursery_rhyme = 'Mary had a little lamb,' \  # These comments
    'its fleece was white as snow.'       \  # are invalid!
    'And everywhere that Mary went,'      \
    'her sheep would surely go.'
# => SyntaxError: unexpected character after line continuation character

Regex字符串的更好注释：

基于以下示例https://docs.python.org/3/library/re.html#re.VERBOSE,

a = re.compile(
    r'\d+'  # the integral part
    r'\.'   # the decimal point
    r'\d*'  # some fractional digits
)

# Using VERBOSE flag, IDE usually can't syntax highight the string comment.
a = re.compile(r"""\d +  # the integral part
                   \.    # the decimal point
                   \d *  # some fractional digits""", re.X)

tl；dr：使用“”和“”来换行字符串，如中所示

string = """\
This is a long string
spanning multiple lines.
"""

从Python官方文档中：

字符串文本可以跨越多行。一种方法是使用三引号：“”“…”“”或“”“”…“”。行的结束是自动的包含在字符串中，但可以通过添加\在线路的末端。以下示例：

print("""\
Usage: thingy [OPTIONS]
     -h                        Display this usage message
     -H hostname               Hostname to connect to
""")

生成以下输出（注意，初始换行符不是包括在内）：

Usage: thingy [OPTIONS]
     -h                        Display this usage message
     -H hostname               Hostname to connect to

我个人认为，以下是用Python编写原始SQL查询的最佳（简单、安全和Python化）方法，尤其是在使用Python的sqlite3模块时：

query = '''
    SELECT
        action.descr as action,
        role.id as role_id,
        role.descr as role
    FROM
        public.role_action_def,
        public.role,
        public.record_def,
        public.action
    WHERE
        role.id = role_action_def.role_id
        AND record_def.id = role_action_def.def_id
        AND action.id = role_action_def.action_id
        AND role_action_def.account_id = ?
        AND record_def.account_id = ?
        AND def_id = ?
'''
vars = (account_id, account_id, def_id)   # a tuple of query variables
cursor.execute(query, vars)   # using Python's sqlite3 module

Pros

整洁而简单的代码（Pythonic！）避免SQL注入与Python 2和Python 3兼容（毕竟是Pythonic）不需要字符串串联无需确保每行最右边的字符是空格

Cons

由于查询中的变量被替换为？占位符，它可能会变得有点难以跟踪哪个？当查询中有很多Python变量时，将由哪个Python变量替换。