最好和最简单的解决方案是使用pygtail: https://pypi.python.org/pypi/pygtail

from pygtail import Pygtail
import sys

while True:
    for line in Pygtail("some.log"):
        sys.stdout.write(line)

看看pyinotify。

Inotify在新的linux中取代了dnotify(从以前的答案)，并允许文件级而不是目录级监控。

对我来说，最简单的解决方法就是使用看门狗的工具watchmedo

从https://pypi.python.org/pypi/watchdog我现在有一个进程，在一个目录中查找sql文件，并在必要时执行它们。

watchmedo shell-command \
--patterns="*.sql" \
--recursive \
--command='~/Desktop/load_files_into_mysql_database.sh' \
.

下面是一个示例，用于观察每秒写入不超过一行但通常要少得多的输入文件。目标是将最后一行(最近的写入)追加到指定的输出文件。我从我的一个项目中复制了这个，只是删除了所有不相关的行。你必须填写或修改缺失的符号。

from PyQt5.QtCore import QFileSystemWatcher, QSettings, QThread
from ui_main_window import Ui_MainWindow   # Qt Creator gen'd 

class MainWindow(QMainWindow, Ui_MainWindow):
    def __init__(self, parent=None):
        QMainWindow.__init__(self, parent)
        Ui_MainWindow.__init__(self)
        self._fileWatcher = QFileSystemWatcher()
        self._fileWatcher.fileChanged.connect(self.fileChanged)

    def fileChanged(self, filepath):
        QThread.msleep(300)    # Reqd on some machines, give chance for write to complete
        # ^^ About to test this, may need more sophisticated solution
        with open(filepath) as file:
            lastLine = list(file)[-1]
        destPath = self._filemap[filepath]['dest file']
        with open(destPath, 'a') as out_file:               # a= append
            out_file.writelines([lastLine])

当然，并不是严格要求包含QMainWindow类。您可以单独使用QFileSystemWatcher。

ACTIONS = {
  1 : "Created",
  2 : "Deleted",
  3 : "Updated",
  4 : "Renamed from something",
  5 : "Renamed to something"
}
FILE_LIST_DIRECTORY = 0x0001

class myThread (threading.Thread):
    def __init__(self, threadID, fileName, directory, origin):
        threading.Thread.__init__(self)
        self.threadID = threadID
        self.fileName = fileName
        self.daemon = True
        self.dir = directory
        self.originalFile = origin
    def run(self):
        startMonitor(self.fileName, self.dir, self.originalFile)

def startMonitor(fileMonitoring,dirPath,originalFile):
    hDir = win32file.CreateFile (
        dirPath,
        FILE_LIST_DIRECTORY,
        win32con.FILE_SHARE_READ | win32con.FILE_SHARE_WRITE,
        None,
        win32con.OPEN_EXISTING,
        win32con.FILE_FLAG_BACKUP_SEMANTICS,
        None
    )
    # Wait for new data and call ProcessNewData for each new chunk that's
    # written
    while 1:
        # Wait for a change to occur
        results = win32file.ReadDirectoryChangesW (
            hDir,
            1024,
            False,
            win32con.FILE_NOTIFY_CHANGE_LAST_WRITE,
            None,
            None
        )
        # For each change, check to see if it's updating the file we're
        # interested in
        for action, file_M in results:
            full_filename = os.path.join (dirPath, file_M)
            #print file, ACTIONS.get (action, "Unknown")
            if len(full_filename) == len(fileMonitoring) and action == 3:
                #copy to main file
                ...

为了用轮询和最小依赖来观察单个文件，下面是一个完整的例子，基于Deestan的回答(上面):

import os
import sys 
import time

class Watcher(object):
    running = True
    refresh_delay_secs = 1

    # Constructor
    def __init__(self, watch_file, call_func_on_change=None, *args, **kwargs):
        self._cached_stamp = 0
        self.filename = watch_file
        self.call_func_on_change = call_func_on_change
        self.args = args
        self.kwargs = kwargs

    # Look for changes
    def look(self):
        stamp = os.stat(self.filename).st_mtime
        if stamp != self._cached_stamp:
            self._cached_stamp = stamp
            # File has changed, so do something...
            print('File changed')
            if self.call_func_on_change is not None:
                self.call_func_on_change(*self.args, **self.kwargs)

    # Keep watching in a loop        
    def watch(self):
        while self.running: 
            try: 
                # Look for changes
                time.sleep(self.refresh_delay_secs) 
                self.look() 
            except KeyboardInterrupt: 
                print('\nDone') 
                break 
            except FileNotFoundError:
                # Action on file not found
                pass
            except: 
                print('Unhandled error: %s' % sys.exc_info()[0])

# Call this function each time a change happens
def custom_action(text):
    print(text)

watch_file = 'my_file.txt'

# watcher = Watcher(watch_file)  # simple
watcher = Watcher(watch_file, custom_action, text='yes, changed')  # also call custom action function
watcher.watch()  # start the watch going