对于iOS7或更高版本，更简洁的方法是使用INFINITY而不是硬编码的值。当屏幕旋转时，您不必担心更新单元格。

if (indexPath.row == <row number>) {
    cell.separatorInset = UIEdgeInsetsMake(0, INFINITY, 0, 0);
}

当我使用扩展和调用layoutSubviews()立即更新布局视图时，它为我工作。

extension UITableViewCell {

    func removeSeparator() {
        separatorInset = UIEdgeInsetsMake(0, bounds.size.width, 0, 0)
    }
}

override func layoutSubviews() {
    super.layoutSubviews()

    removeSeparator()
}

除非使用以下解决方法，否则无法在特定单元格上隐藏分隔符

- (void)layoutSubviews {
    [super layoutSubviews];
    [self hideCellSeparator];
}
// workaround
- (void)hideCellSeparator {
    for (UIView *view in  self.subviews) {
        if (![view isKindOfClass:[UIControl class]]) {
            [view removeFromSuperview];
        }
    }
}

cell.separatorInset = UIEdgeInsetsMake(0.0, cell.bounds.size.width, 0.0, -cell.bounds.size.width)

在iOS 10.2中运行良好

你必须采取自定义单元格，并添加标签和设置约束，如标签应覆盖整个单元格区域。 并在构造函数中编写下面的行。

- (void)awakeFromNib {
    // Initialization code
    self.separatorInset = UIEdgeInsetsMake(0, 10000, 0, 0);
    //self.layoutMargins = UIEdgeInsetsZero;
    [self setBackgroundColor:[UIColor clearColor]];
    [self setSelectionStyle:UITableViewCellSelectionStyleNone];
}

也设置UITableView布局边距如下

tblSignup.layoutMargins = UIEdgeInsetsZero;

实现这一点的最好方法是关闭默认的行分隔符，子类UITableViewCell，并添加一个自定义的行分隔符作为contentView的子视图-参见下面的自定义单元格，用于表示一个SNStock类型的对象，它有两个字符串属性，ticker和name:

import UIKit

private let kSNStockCellCellHeight: CGFloat = 65.0
private let kSNStockCellCellLineSeparatorHorizontalPaddingRatio: CGFloat = 0.03
private let kSNStockCellCellLineSeparatorBackgroundColorAlpha: CGFloat = 0.3
private let kSNStockCellCellLineSeparatorHeight: CGFloat = 1

class SNStockCell: UITableViewCell {

  private let primaryTextColor: UIColor
  private let secondaryTextColor: UIColor

  private let customLineSeparatorView: UIView

  var showsCustomLineSeparator: Bool {
    get {
      return !customLineSeparatorView.hidden
    }
    set(showsCustomLineSeparator) {
      customLineSeparatorView.hidden = !showsCustomLineSeparator
    }
  }

  var customLineSeparatorColor: UIColor? {
   get {
     return customLineSeparatorView.backgroundColor
   }
   set(customLineSeparatorColor) {
     customLineSeparatorView.backgroundColor = customLineSeparatorColor?.colorWithAlphaComponent(kSNStockCellCellLineSeparatorBackgroundColorAlpha)
    }
  }

  required init(coder aDecoder: NSCoder) {
    fatalError("init(coder:) has not been implemented")
  }

  init(reuseIdentifier: String, primaryTextColor: UIColor, secondaryTextColor: UIColor) {
    self.primaryTextColor = primaryTextColor
    self.secondaryTextColor = secondaryTextColor
    self.customLineSeparatorView = UIView(frame:CGRectZero)
    super.init(style: UITableViewCellStyle.Subtitle, reuseIdentifier:reuseIdentifier)
    selectionStyle = UITableViewCellSelectionStyle.None
    backgroundColor = UIColor.clearColor()

    contentView.addSubview(customLineSeparatorView)
    customLineSeparatorView.hidden = true
  }

  override func prepareForReuse() {
    super.prepareForReuse()
    self.showsCustomLineSeparator = false
  }

  // MARK: Layout

  override func layoutSubviews() {
    super.layoutSubviews()
    layoutCustomLineSeparator()
  }

  private func layoutCustomLineSeparator() {
    let horizontalPadding: CGFloat = bounds.width * kSNStockCellCellLineSeparatorHorizontalPaddingRatio
    let lineSeparatorWidth: CGFloat = bounds.width - horizontalPadding * 2;
    customLineSeparatorView.frame = CGRectMake(horizontalPadding,
      kSNStockCellCellHeight - kSNStockCellCellLineSeparatorHeight,
      lineSeparatorWidth,
      kSNStockCellCellLineSeparatorHeight)
  }

  // MARK: Public Class API

  class func cellHeight() -> CGFloat {
    return kSNStockCellCellHeight
  }

  // MARK: Public API

  func configureWithStock(stock: SNStock) {
    textLabel!.text = stock.ticker as String
    textLabel!.textColor = primaryTextColor
    detailTextLabel!.text = stock.name as String
    detailTextLabel!.textColor = secondaryTextColor
    setNeedsLayout()
  } 
}

要禁用默认的行分隔符，请使用tableView。separatorStyle = UITableViewCellSeparatorStyle.None;消费者方面相对简单，见下面的例子:

private func stockCell(tableView: UITableView, indexPath:NSIndexPath) -> UITableViewCell {
  var cell : SNStockCell? = tableView.dequeueReusableCellWithIdentifier(stockCellReuseIdentifier) as? SNStockCell
  if (cell == nil) {
    cell = SNStockCell(reuseIdentifier:stockCellReuseIdentifier, primaryTextColor:primaryTextColor, secondaryTextColor:secondaryTextColor)
  }
  cell!.configureWithStock(stockAtIndexPath(indexPath))
  cell!.showsCustomLineSeparator = true
  cell!.customLineSeparatorColor = tintColor
  return cell!
}