迅速:

override func viewDidLoad() {
    super.viewDidLoad()

    if self.tableView.respondsToSelector("setSeparatorInset:") {
        self.tableView.separatorInset = UIEdgeInsetsZero
    }
    if self.tableView.respondsToSelector("setLayoutMargins:") {
        self.tableView.layoutMargins = UIEdgeInsetsZero
    }

    self.tableView.layoutIfNeeded()            // <--- this do the magic
}

override func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell {
     ...

    if cell.respondsToSelector("setSeparatorInset:") {
        cell.separatorInset = UIEdgeInsetsZero
    }
    if cell.respondsToSelector("setLayoutMargins:") {
        cell.layoutMargins = UIEdgeInsetsZero
    }

    return cell
}

至于cdstamper建议的表格视图，在单元格的layoutSubview方法中添加以下行对我来说是可行的。

- (void)layoutSubviews 
{
    [super layoutSubviews];

    if ([self respondsToSelector:@selector(setSeparatorInset:)])
                [self setSeparatorInset:UIEdgeInsetsZero];

        if ([self respondsToSelector:@selector(setPreservesSuperviewLayoutMargins:)])
        {
            [self setPreservesSuperviewLayoutMargins:NO];;
        }

        if ([self respondsToSelector:@selector(setLayoutMargins:)]) 
        {
            [self setLayoutMargins:UIEdgeInsetsZero];
        }
}

使用Swift 2.2

创建UITableViewCell扩展

import UIKit

extension UITableViewCell {
    func removeMargins() {

        if self.respondsToSelector(Selector("setSeparatorInset:")) {
            self.separatorInset = UIEdgeInsetsZero
        }

        if self.respondsToSelector(Selector("setPreservesSuperviewLayoutMargins:")) {
            self.preservesSuperviewLayoutMargins = false
        }

        if self.respondsToSelector(Selector("setLayoutMargins:")) {
            self.layoutMargins = UIEdgeInsetsZero
        }
    }
} 

现在可以在cellForRowAtIndex中使用

-(void)tableView:(UITableView *)tableView willDisplayCell:(UITableViewCell *)cell forRowAtIndexPath:(NSIndexPath *)indexPath
{
            cell.removeMargins()//To remove seprator inset 
}

Swift 2.0扩展

我只是想分享一个扩展，我做了删除边缘从tableview单元格分隔符。

extension UITableViewCell {
    func removeMargins() {

        if self.respondsToSelector("setSeparatorInset:") {
            self.separatorInset = UIEdgeInsetsZero
        }

        if self.respondsToSelector("setPreservesSuperviewLayoutMargins:") {
            self.preservesSuperviewLayoutMargins = false
        }

        if self.respondsToSelector("setLayoutMargins:") {
            self.layoutMargins = UIEdgeInsetsZero
        }
    }
}

用于上下文中:

    let cell = tableView.dequeueReusableCellWithIdentifier("Cell", forIndexPath: indexPath) as! CustomCell

    cell.removeMargins()
    return cell

对于iOS 9，你需要添加:

if([myTableView respondsToSelector:@selector(setCellLayoutMarginsFollowReadableWidth:)])
{
    myTableView.cellLayoutMarginsFollowReadableWidth = NO;
} 

详情请参阅问题。

使用storyboard更改分隔符插入自定义左0和右0， 如果你想隐藏分隔符为None 见上图