function logout(url){
    var str = url.replace("http://", "http://" + new Date().getTime() + "@");
    var xmlhttp;
    if (window.XMLHttpRequest) xmlhttp=new XMLHttpRequest();
    else xmlhttp=new ActiveXObject("Microsoft.XMLHTTP");
    xmlhttp.onreadystatechange=function()
    {
        if (xmlhttp.readyState==4) location.reload();
    }
    xmlhttp.open("GET",str,true);
    xmlhttp.setRequestHeader("Authorization","Basic YXNkc2E6")
    xmlhttp.send();
    return false;
}

正如@SalCelli提到的，chrome://restart工作。但是，这会重新启动所有的选项卡。

另一种方法是采用CEGRD建议的隐身模式

但是，如果你不喜欢在Chrome 86 (Mac)上重新启动和隐身使用，我发现@opsb和Mike提供的答案只适用于以下额外步骤。

Enter the wrong username in the url without the resources eg: if the url is http://mywebsite.com/resources/, it will not work if I enter http://wrong@mywebsite.com/resources/, but will work if I enter only http://wrong@mywebsite.com/ it clears the Basic Auth credentials prompt for the credentials again However, entering the valid credentials will not work, as in the background, chrome still send the wrong user as part of the url, even though the url appears right in the address bar When prompted for credentials you would need to Cancel, and click the address bar and reload the page from pressing enter. Now enter the correct password

在Chrome中还没有办法做到这一点(Chrome 58)

我发现最好的解决方案是在隐身窗口中打开url，这将迫使您重新输入基本的身份验证凭据。

当您想要更改凭证时，请关闭隐身窗口并启动另一个隐身窗口。

最奇怪的事情，但在我的情况下，我试图访问一个具有基本认证的页面，Chrome甚至没有提示就发送无效凭据。在我注销了我的LastPass插件后，一切都恢复正常了。所以我认为LastPass开始支持基本身份验证，但它没有提供使用什么密码的选项，它看起来只是为匹配的域发送一个随机密码(这在我的情况下是非常有问题的)。

也许能帮到别人。

退出Chrome时，身份验证将被清除。

Note however, that by default Chrome is running apps in the background, so it may not really exit even if you close all Chrome windows. You can either change this behavior under advanced setting, or e.g. under Windows, you can completely exit Chrome by using the Chrome icon in the systray. There should be an icon if Chrome is still running, but maybe you'll find it only in the popup with the hidden icons. The context menu of the Chrome icon has an entry to completely exit Chrome, and you can also change the setting for running apps in the background using that menu.

打开Chrome菜单 选择设置 滚动到底部 单击“显示高级设置…” 滚动到底部 在“系统”下取消选中“当谷歌Chrome浏览器关闭时继续运行后台应用程序”的复选框

你应该能够清除您的凭据从您的浏览器通过“清除浏览数据…”在chrome://设置/高级