如果有人对此感兴趣，他们可以将优秀的perl模块File::Type移植到。net。在代码中是一组文件头魔术数字查找每个文件类型或正则表达式匹配。

这里有一个。net文件类型检测库http://filetypedetective.codeplex.com/，但它目前只检测少量的文件。

@Steve Morgan和@Richard Gourlay，这是一个很好的解决方案，谢谢你们。一个小缺点是，当文件中的字节数为255或以下时，mime类型有时会产生“application/octet-stream”，这对于期望产生“text/plain”的文件来说有点不准确。对于这种情况，我更新了你原来的方法如下:

如果文件中的字节数小于或等于255，并且推导出的mime类型是"application/octet-stream"，那么创建一个新的字节数组，该数组由重复n次的原始文件字节组成，直到字节总数为>= 256。然后重新检查新字节数组上的mime-type。

修改方法:

Imports System.Runtime.InteropServices

<DllImport("urlmon.dll", CharSet:=CharSet.Auto)> _
Private Shared Function FindMimeFromData(pBC As System.UInt32, <MarshalAs(UnmanagedType.LPStr)> pwzUrl As System.String, <MarshalAs(UnmanagedType.LPArray)> pBuffer As Byte(), cbSize As System.UInt32, <MarshalAs(UnmanagedType.LPStr)> pwzMimeProposed As System.String, dwMimeFlags As System.UInt32, _
ByRef ppwzMimeOut As System.UInt32, dwReserverd As System.UInt32) As System.UInt32
End Function
Private Function GetMimeType(ByVal f As FileInfo) As String
    'See http://stackoverflow.com/questions/58510/using-net-how-can-you-find-the-mime-type-of-a-file-based-on-the-file-signature
    Dim returnValue As String = ""
    Dim fileStream As FileStream = Nothing
    Dim fileStreamLength As Long = 0
    Dim fileStreamIsLessThanBByteSize As Boolean = False

    Const byteSize As Integer = 255
    Const bbyteSize As Integer = byteSize + 1

    Const ambiguousMimeType As String = "application/octet-stream"
    Const unknownMimeType As String = "unknown/unknown"

    Dim buffer As Byte() = New Byte(byteSize) {}
    Dim fnGetMimeTypeValue As New Func(Of Byte(), Integer, String)(
        Function(_buffer As Byte(), _bbyteSize As Integer) As String
            Dim _returnValue As String = ""
            Dim mimeType As UInt32 = 0
            FindMimeFromData(0, Nothing, _buffer, _bbyteSize, Nothing, 0, mimeType, 0)
            Dim mimeTypePtr As IntPtr = New IntPtr(mimeType)
            _returnValue = Marshal.PtrToStringUni(mimeTypePtr)
            Marshal.FreeCoTaskMem(mimeTypePtr)
            Return _returnValue
        End Function)

    If (f.Exists()) Then
        Try
            fileStream = New FileStream(f.FullName(), FileMode.Open, FileAccess.Read, FileShare.ReadWrite)
            fileStreamLength = fileStream.Length()

            If (fileStreamLength >= bbyteSize) Then
                fileStream.Read(buffer, 0, bbyteSize)
            Else
                fileStreamIsLessThanBByteSize = True
                fileStream.Read(buffer, 0, CInt(fileStreamLength))
            End If

            returnValue = fnGetMimeTypeValue(buffer, bbyteSize)

            If (returnValue.Equals(ambiguousMimeType, StringComparison.OrdinalIgnoreCase) AndAlso fileStreamIsLessThanBByteSize AndAlso fileStreamLength > 0) Then
                'Duplicate the stream content until the stream length is >= bbyteSize to get a more deterministic mime type analysis.
                Dim currentBuffer As Byte() = buffer.Take(fileStreamLength).ToArray()
                Dim repeatCount As Integer = Math.Floor((bbyteSize / fileStreamLength) + 1)
                Dim bBufferList As List(Of Byte) = New List(Of Byte)
                While (repeatCount > 0)
                    bBufferList.AddRange(currentBuffer)
                    repeatCount -= 1
                End While
                Dim bbuffer As Byte() = bBufferList.Take(bbyteSize).ToArray()
                returnValue = fnGetMimeTypeValue(bbuffer, bbyteSize)
            End If
        Catch ex As Exception
            returnValue = unknownMimeType
        Finally
            If (fileStream IsNot Nothing) Then fileStream.Close()
        End Try
    End If
    Return returnValue
End Function

在Urlmon.dll中，有一个名为FindMimeFromData的函数。

来自文档

MIME类型检测或“数据嗅探”是指从二进制数据中确定适当的MIME类型的过程。最终结果取决于服务器提供的MIME类型头、文件扩展名和/或数据本身的组合。通常，只有前256字节的数据是重要的。

因此，从文件中读取第一个(最多)256字节，并将其传递给FindMimeFromData。

你好，我已经改编了Winista。MimeDetect项目到。net core/framework，回退到urlmon.dll，自由使用它:nuget包。

   //init
   var mimeTypes = new MimeTypes();

   //usage by filepath
   var mimeType1 = mimeTypes.GetMimeTypeFromFile(filePath);

最后我确实使用了urlmon.dll。我本以为有更简单的方法，但这招管用。我包含了代码来帮助其他人，并允许我在需要时再次找到它。

using System.Runtime.InteropServices;

...

    [DllImport(@"urlmon.dll", CharSet = CharSet.Auto)]
    private extern static System.UInt32 FindMimeFromData(
        System.UInt32 pBC,
        [MarshalAs(UnmanagedType.LPStr)] System.String pwzUrl,
        [MarshalAs(UnmanagedType.LPArray)] byte[] pBuffer,
        System.UInt32 cbSize,
        [MarshalAs(UnmanagedType.LPStr)] System.String pwzMimeProposed,
        System.UInt32 dwMimeFlags,
        out System.UInt32 ppwzMimeOut,
        System.UInt32 dwReserverd
    );

    public static string getMimeFromFile(string filename)
    {
        if (!File.Exists(filename))
            throw new FileNotFoundException(filename + " not found");

        byte[] buffer = new byte[256];
        using (FileStream fs = new FileStream(filename, FileMode.Open))
        {
            if (fs.Length >= 256)
                fs.Read(buffer, 0, 256);
            else
                fs.Read(buffer, 0, (int)fs.Length);
        }
        try
        {
            System.UInt32 mimetype;
            FindMimeFromData(0, null, buffer, 256, null, 0, out mimetype, 0);
            System.IntPtr mimeTypePtr = new IntPtr(mimetype);
            string mime = Marshal.PtrToStringUni(mimeTypePtr);
            Marshal.FreeCoTaskMem(mimeTypePtr);
            return mime;
        }
        catch (Exception e)
        {
            return "unknown/unknown";
        }
    }

iis7或以上

使用此代码，但您需要是服务器上的管理员

public bool CheckMimeMapExtension(string fileExtension)
        {
            try
            {

                using (
                ServerManager serverManager = new ServerManager())
                {   
                    // connects to default app.config
                    var config = serverManager.GetApplicationHostConfiguration();
                    var staticContent = config.GetSection("system.webServer/staticContent");
                    var mimeMap = staticContent.GetCollection();

                    foreach (var mimeType in mimeMap)
                    {

                        if (((String)mimeType["fileExtension"]).Equals(fileExtension, StringComparison.OrdinalIgnoreCase))
                            return true;

                    }

                }
                return false;
            }
            catch (Exception ex)
            { 
                Console.WriteLine("An exception has occurred: \n{0}", ex.Message);
                Console.Read();
            }

            return false;

        }