对于只替换一个字符，使用翻译和str.maketrans是我最喜欢的方法。

Tl;dr > result_string = your_string.translate(str.maketrans(dict_mapping))

demo

my_string = 'This is a test string.'
dict_mapping = {'i': 's', 's': 'S'}
result_good = my_string.translate(str.maketrans(dict_mapping))
result_bad = my_string
for x, y in dict_mapping.items():
    result_bad = result_bad.replace(x, y)
print(result_good)  # ThsS sS a teSt Strsng.
print(result_bad)   # ThSS SS a teSt StrSng.

在我的情况下，我需要一个简单的唯一键替换名称，所以我想到了这个:

a = 'This is a test string.'
b = {'i': 'I', 's': 'S'}
for x,y in b.items():
    a = a.replace(x, y)
>>> a
'ThIS IS a teSt StrIng.'

这里有一个使用reduce的第一个解决方案的变体，如果你喜欢功能性的。：）

repls = {'hello' : 'goodbye', 'world' : 'earth'}
s = 'hello, world'
reduce(lambda a, kv: a.replace(*kv), repls.iteritems(), s)

马蒂诺的版本更好:

repls = ('hello', 'goodbye'), ('world', 'earth')
s = 'hello, world'
reduce(lambda a, kv: a.replace(*kv), repls, s)

我想建议使用字符串模板。只需将要替换的字符串放在字典中，一切就都设置好了!示例来自docs.python.org

>>> from string import Template
>>> s = Template('$who likes $what')
>>> s.substitute(who='tim', what='kung pao')
'tim likes kung pao'
>>> d = dict(who='tim')
>>> Template('Give $who $100').substitute(d)
Traceback (most recent call last):
[...]
ValueError: Invalid placeholder in string: line 1, col 10
>>> Template('$who likes $what').substitute(d)
Traceback (most recent call last):
[...]
KeyError: 'what'
>>> Template('$who likes $what').safe_substitute(d)
'tim likes $what'

注意:测试你的案例，见注释。

这里有一个例子，它在长弦上更有效，有许多小的替换。

source = "Here is foo, it does moo!"

replacements = {
    'is': 'was', # replace 'is' with 'was'
    'does': 'did',
    '!': '?'
}

def replace(source, replacements):
    finder = re.compile("|".join(re.escape(k) for k in replacements.keys())) # matches every string we want replaced
    result = []
    pos = 0
    while True:
        match = finder.search(source, pos)
        if match:
            # cut off the part up until match
            result.append(source[pos : match.start()])
            # cut off the matched part and replace it in place
            result.append(replacements[source[match.start() : match.end()]])
            pos = match.end()
        else:
            # the rest after the last match
            result.append(source[pos:])
            break
    return "".join(result)

print replace(source, replacements)

关键是要避免长字符串的多次连接。我们将源字符串切成片段，在我们形成列表时替换一些片段，然后将整个字符串连接回字符串。

为什么没有这样的解决方案呢?

s = "The quick brown fox jumps over the lazy dog"
for r in (("brown", "red"), ("lazy", "quick")):
    s = s.replace(*r)

#output will be:  The quick red fox jumps over the quick dog