在你的UITableViewCell子类中，覆盖layoutSubviews并隐藏_UITableViewCellSeparatorView。适用于iOS 10。

override func layoutSubviews() {
    super.layoutSubviews()

    subviews.forEach { (view) in
        if view.dynamicType.description() == "_UITableViewCellSeparatorView" {
            view.hidden = true
        }
    }
}

在willdisplaycell:

cell.separatorInset = UIEdgeInsetsMake(0, cell.bounds.size.width, 0, 0)

- (void)viewDidLoad {
    [super viewDidLoad];
    // Do any additional setup after loading the view.
    [self.tableView setSeparatorStyle:UITableViewCellSeparatorStyleNone];
}

实现这一点的最好方法是关闭默认的行分隔符，子类UITableViewCell，并添加一个自定义的行分隔符作为contentView的子视图-参见下面的自定义单元格，用于表示一个SNStock类型的对象，它有两个字符串属性，ticker和name:

import UIKit

private let kSNStockCellCellHeight: CGFloat = 65.0
private let kSNStockCellCellLineSeparatorHorizontalPaddingRatio: CGFloat = 0.03
private let kSNStockCellCellLineSeparatorBackgroundColorAlpha: CGFloat = 0.3
private let kSNStockCellCellLineSeparatorHeight: CGFloat = 1

class SNStockCell: UITableViewCell {

  private let primaryTextColor: UIColor
  private let secondaryTextColor: UIColor

  private let customLineSeparatorView: UIView

  var showsCustomLineSeparator: Bool {
    get {
      return !customLineSeparatorView.hidden
    }
    set(showsCustomLineSeparator) {
      customLineSeparatorView.hidden = !showsCustomLineSeparator
    }
  }

  var customLineSeparatorColor: UIColor? {
   get {
     return customLineSeparatorView.backgroundColor
   }
   set(customLineSeparatorColor) {
     customLineSeparatorView.backgroundColor = customLineSeparatorColor?.colorWithAlphaComponent(kSNStockCellCellLineSeparatorBackgroundColorAlpha)
    }
  }

  required init(coder aDecoder: NSCoder) {
    fatalError("init(coder:) has not been implemented")
  }

  init(reuseIdentifier: String, primaryTextColor: UIColor, secondaryTextColor: UIColor) {
    self.primaryTextColor = primaryTextColor
    self.secondaryTextColor = secondaryTextColor
    self.customLineSeparatorView = UIView(frame:CGRectZero)
    super.init(style: UITableViewCellStyle.Subtitle, reuseIdentifier:reuseIdentifier)
    selectionStyle = UITableViewCellSelectionStyle.None
    backgroundColor = UIColor.clearColor()

    contentView.addSubview(customLineSeparatorView)
    customLineSeparatorView.hidden = true
  }

  override func prepareForReuse() {
    super.prepareForReuse()
    self.showsCustomLineSeparator = false
  }

  // MARK: Layout

  override func layoutSubviews() {
    super.layoutSubviews()
    layoutCustomLineSeparator()
  }

  private func layoutCustomLineSeparator() {
    let horizontalPadding: CGFloat = bounds.width * kSNStockCellCellLineSeparatorHorizontalPaddingRatio
    let lineSeparatorWidth: CGFloat = bounds.width - horizontalPadding * 2;
    customLineSeparatorView.frame = CGRectMake(horizontalPadding,
      kSNStockCellCellHeight - kSNStockCellCellLineSeparatorHeight,
      lineSeparatorWidth,
      kSNStockCellCellLineSeparatorHeight)
  }

  // MARK: Public Class API

  class func cellHeight() -> CGFloat {
    return kSNStockCellCellHeight
  }

  // MARK: Public API

  func configureWithStock(stock: SNStock) {
    textLabel!.text = stock.ticker as String
    textLabel!.textColor = primaryTextColor
    detailTextLabel!.text = stock.name as String
    detailTextLabel!.textColor = secondaryTextColor
    setNeedsLayout()
  } 
}

要禁用默认的行分隔符，请使用tableView。separatorStyle = UITableViewCellSeparatorStyle.None;消费者方面相对简单，见下面的例子:

private func stockCell(tableView: UITableView, indexPath:NSIndexPath) -> UITableViewCell {
  var cell : SNStockCell? = tableView.dequeueReusableCellWithIdentifier(stockCellReuseIdentifier) as? SNStockCell
  if (cell == nil) {
    cell = SNStockCell(reuseIdentifier:stockCellReuseIdentifier, primaryTextColor:primaryTextColor, secondaryTextColor:secondaryTextColor)
  }
  cell!.configureWithStock(stockAtIndexPath(indexPath))
  cell!.showsCustomLineSeparator = true
  cell!.customLineSeparatorColor = tintColor
  return cell!
}

在Swift 3, Swift 4和Swift 5中，你可以像这样写一个UITableViewCell扩展:

extension UITableViewCell {
  func separator(hide: Bool) {
    separatorInset.left = hide ? bounds.size.width : 0
  }
}

然后你可以这样使用它(当cell是你的cell实例时):

cell.separator(hide: false) // Shows separator 
cell.separator(hide: true) // Hides separator

将表格视图单元格的宽度赋为左插入值比赋给它一些随机数更好。因为在某些屏幕尺寸中，也许不是现在，但将来你的分隔符仍然是可见的因为这个随机数可能不够。此外，在iPad横屏模式下，你不能保证你的分隔符总是不可见。

来跟进Hiren的回答。

在ViewDidLoad和下面一行:

self.tableView.separatorStyle = UITableViewCellSeparatorStyleNone;

或者，如果你正在使用XIB或storyboard，将“separator”更改为“none”:

在CellForRowAtIndexPath中添加这个:

CGFloat separatorInset; // Separator x position 
CGFloat separatorHeight; 
CGFloat separatorWidth; 
CGFloat separatorY; 
UIImageView *separator;
UIColor *separatorBGColor;

separatorY      = cell.frame.size.height;
separatorHeight = (1.0 / [UIScreen mainScreen].scale);  // This assures you to have a 1px line height whatever the screen resolution
separatorWidth  = cell.frame.size.width;
separatorInset  = 15.0f;
separatorBGColor  = [UIColor colorWithRed: 204.0/255.0 green: 204.0/255.0 blue: 204.0/255.0 alpha:1.0];

separator = [[UIImageView alloc] initWithFrame:CGRectMake(separatorInset, separatorY, separatorWidth,separatorHeight)];
separator.backgroundColor = separatorBGColor;
[cell addSubView: separator];

这是一个结果的例子，我显示一个动态单元格的tableview(但只有一个内容)。结果是，只有一个有分隔符，而不是所有的“虚拟”tableview自动添加填充屏幕。

编辑:对于那些不经常阅读注释的人来说，实际上有一种更好的方法，只需几行代码:

override func viewDidLoad() {
    super.viewDidLoad()
    tableView.tableFooterView = UIView()
}