使用Swift 3并采用最快的黑客方法，您可以使用扩展来改进代码:

extension UITableViewCell {

    var isSeparatorHidden: Bool {
        get {
            return self.separatorInset.right != 0
        }
        set {
            if newValue {
                self.separatorInset = UIEdgeInsetsMake(0, self.bounds.size.width, 0, 0)
            } else {
                self.separatorInset = UIEdgeInsetsMake(0, 0, 0, 0)
            }
        }
    }

}

然后，当你配置单元格时:

func tableView(_ tableView: UITableView, cellForRowAt indexPath: IndexPath) -> UITableViewCell {
    let cell = collectionView.dequeueReusableCell(withReuseIdentifier: "identifier", for: indexPath)
    switch indexPath.row {
       case 3:
          cell.isSeparatorHidden = true
       default:
          cell.isSeparatorHidden = false
    }
    return cell
}

func tableView(_ tableView: UITableView, didSelectRowAt indexPath: IndexPath) {
    let cell = tableView.cellForRow(at: indexPath)
    if cell.isSeparatorHidden { 
       // do stuff
    }
}

- (UITableViewCell *)tableView:(UITableView *)tableView cellForRowAtIndexPath:(NSIndexPath *)indexPath {

       NSString *cellId = @"cell";
       UITableViewCell *cell = [tableView dequeueReusableCellWithIdentifier:cellId];
       NSInteger lastRowIndexInSection = [tableView numberOfRowsInSection:indexPath.section] - 1;

       if (row == lastRowIndexInSection) {
              CGFloat halfWidthOfCell = cell.frame.size.width / 2;
              cell.separatorInset = UIEdgeInsetsMake(0, halfWidthOfCell, 0, halfWidthOfCell);
       }
}

除非使用以下解决方法，否则无法在特定单元格上隐藏分隔符

- (void)layoutSubviews {
    [super layoutSubviews];
    [self hideCellSeparator];
}
// workaround
- (void)hideCellSeparator {
    for (UIView *view in  self.subviews) {
        if (![view isKindOfClass:[UIControl class]]) {
            [view removeFromSuperview];
        }
    }
}

使用这个子类，set separatorInset在iOS 9.2.1中不起作用，内容会被压缩。

@interface NSPZeroMarginCell : UITableViewCell

@property (nonatomic, assign) BOOL separatorHidden;

@end

@implementation NSPZeroMarginCell

- (void) layoutSubviews {
    [super layoutSubviews];

    for (UIView *view in  self.subviews) {
        if (![view isKindOfClass:[UIControl class]]) {
            if (CGRectGetHeight(view.frame) < 3) {
                view.hidden = self.separatorHidden;
            }
        }
    }
}

@end

https://gist.github.com/liruqi/9a5add4669e8d9cd3ee9

对于iOS7或更高版本，更简洁的方法是使用INFINITY而不是硬编码的值。当屏幕旋转时，您不必担心更新单元格。

if (indexPath.row == <row number>) {
    cell.separatorInset = UIEdgeInsetsMake(0, INFINITY, 0, 0);
}

  if([_data count] == 0 ){
       [self.tableView setSeparatorStyle:UITableViewCellSeparatorStyleNone];//  [self tableView].=YES;
    } else {
      [self.tableView setSeparatorStyle:UITableViewCellSeparatorStyleSingleLine];////    [self tableView].hidden=NO;
    }