根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

在UITextView或UILabel扩展中，添加这个函数:

我添加了一些代码来保持当前的带属性文本，如果您已经在视图中使用带属性字符串(而不是覆盖它们)。

func setLineHeight(_ lineHeight: CGFloat) {
    guard let text = self.text, let font = self.font else { return }

    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineSpacing = 1.0
    paragraphStyle.lineHeightMultiple = lineHeight
    paragraphStyle.alignment = self.textAlignment

    var attrString:NSMutableAttributedString
    if let attributed = self.attributedText {
        attrString = NSMutableAttributedString(attributedString: attributed)
    } else {
        attrString = NSMutableAttributedString(string: text)
        attrString.addAttribute(NSFontAttributeName, value: font, range: NSMakeRange(0, attrString.length))
    }
    attrString.addAttribute(NSParagraphStyleAttributeName, value:paragraphStyle, range:NSMakeRange(0, attrString.length))
    self.attributedText = attrString
}

SWIFT 3有用的扩展设置行间的空间更容易:)

extension UILabel
{
    func setLineHeight(lineHeight: CGFloat)
    {
        let text = self.text
        if let text = text 
        {

            let attributeString = NSMutableAttributedString(string: text)
            let style = NSMutableParagraphStyle()

           style.lineSpacing = lineHeight
           attributeString.addAttribute(NSParagraphStyleAttributeName,
                                        value: style,
                                        range: NSMakeRange(0, text.characters.count))

           self.attributedText = attributeString
        }
    }
}

这段代码适用于我(ios 7和ios 8肯定是如此)。

_label.numberOfLines=2;
_label.textColor=[UIColor whiteColor];

NSMutableParagraphStyle *paragraphStyle = [[NSMutableParagraphStyle alloc] init];
paragraphStyle.lineHeightMultiple=0.5;
paragraphStyle.alignment = NSTextAlignmentCenter;
paragraphStyle.lineSpacing = 1.0;

NSDictionary *nameAttributes=@{
                               NSParagraphStyleAttributeName : paragraphStyle,
                               NSBaselineOffsetAttributeName:@2.0
                               };


NSAttributedString *string=[[NSAttributedString alloc] initWithString:@"22m\nago" attributes:nameAttributes];
_label.attributedText=string;

在Swift中，作为一个函数，灵感来自DarkDust

// Usage: setTextWithLineSpacing(myEpicUILabel,text:"Hello",lineSpacing:20)
func setTextWithLineSpacing(label:UILabel,text:String,lineSpacing:CGFloat)
{
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineSpacing = lineSpacing

    let attrString = NSMutableAttributedString(string: text)
    attrString.addAttribute(NSAttributedString.Key.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))

    label.attributedText = attrString
}

下面是一个子类UILabel具有行高属性的类:https://github.com/LemonCake/MSLabel