我做了这个简单的扩展，非常适合我:

extension UILabel {
    func setLineHeight(lineHeight: CGFloat) {
        let paragraphStyle = NSMutableParagraphStyle()
        paragraphStyle.lineSpacing = 1.0
        paragraphStyle.lineHeightMultiple = lineHeight
        paragraphStyle.alignment = self.textAlignment

        let attrString = NSMutableAttributedString()
        if (self.attributedText != nil) {
            attrString.append( self.attributedText!)
        } else {
            attrString.append( NSMutableAttributedString(string: self.text!))
            attrString.addAttribute(NSAttributedStringKey.font, value: self.font, range: NSMakeRange(0, attrString.length))
        }
        attrString.addAttribute(NSAttributedStringKey.paragraphStyle, value:paragraphStyle, range:NSMakeRange(0, attrString.length))
        self.attributedText = attrString
    }
}

复制到一个文件中，这样你就可以像这样使用它了

myLabel.setLineHeight(0.7)

另一个答案……如果你通过编程的方式传递字符串，你需要传递一个带属性的字符串，而不是一个普通的字符串，并改变它的风格。

NSMutableAttributedString * attrString = [[NSMutableAttributedString alloc] initWithString:@"Your \nregular \nstring"];
NSMutableParagraphStyle *style = [[NSMutableParagraphStyle alloc] init];
[style setLineSpacing:4];
[attrString addAttribute:NSParagraphStyleAttributeName
                   value:style
                   range:NSMakeRange(0, attrString.length)];
_label.attributedText = attrString;

Swift 3扩展:

import UIKit
    
extension UILabel {
  func setTextWithLineSpacing(text: String, lineHeightMultiply: CGFloat = 1.3) {
    let paragraphStyle = NSMutableParagraphStyle()
    paragraphStyle.lineHeightMultiple = lineHeightMultiply
    paragraphStyle.alignment = .center
    let attributedString = NSMutableAttributedString(string: text)
    attributedString.addAttribute(NSParagraphStyleAttributeName, value: paragraphStyle, range: NSRange(location: 0, length: attributedString.length))
    self.attributedText = attributedString
  }
}

Swift 4标签扩展。在传入函数之前创建NSMutableAttributedString，以防有属性文本需要额外的属性。

extension UILabel {

    func setLineHeightMultiple(to height: CGFloat, withAttributedText attributedText: NSMutableAttributedString) {

        let paragraphStyle = NSMutableParagraphStyle()
        paragraphStyle.lineSpacing = 1.0
        paragraphStyle.lineHeightMultiple = height
        paragraphStyle.alignment = textAlignment

        attributedText.addAttribute(.paragraphStyle, value: paragraphStyle, range: NSRange(location: 0, length: attributedText.length - 1))

        self.attributedText = attributedText
    }
}

根据@Mike的回答，减少lineHeightMultiple是关键点。下面的例子，它很适合我:

NSString* text = label.text;
CGFloat textWidth = [text sizeWithAttributes:@{NSFontAttributeName: label.font}].width;
if (textWidth > label.frame.size.width) {
  NSMutableParagraphStyle *paragraph = [[NSMutableParagraphStyle alloc] init];
  paragraph.alignment = NSTextAlignmentCenter;
  paragraph.lineSpacing = 1.0f;
  paragraph.lineHeightMultiple = 0.75;     // Reduce this value !!!
  NSMutableAttributedString* attrText = [[NSMutableAttributedString alloc] initWithString:text];
  [attrText addAttribute:NSParagraphStyleAttributeName value:paragraph range:NSMakeRange(0, text.length)];
  label.attributedText = attrText;
}

在Xcode 6中，你可以在storyboard中这样做: