你可以试试

var strArr = str.split("");

strArr[0] = 'h';

str = strArr.join("");

我做了一个类似于你问的函数，它检查字符串中的字符是否在不允许字符数组中如果是它就用"

    var validate = function(value){
        var notAllowed = [";","_",">","<","'","%","$","&","/","|",":","=","*"];
        for(var i=0; i<value.length; i++){
            if(notAllowed.indexOf(value.charAt(i)) > -1){
               value = value.replace(value.charAt(i), "");
               value = validate(value);
            }
       }
      return value;
   }

function dothis() { var x = document.getElementById("x").value; var index = document.getElementById("index").value; var text = document.getElementById("text").value; var length = document.getElementById("length").value; var arr = x.split(""); arr.splice(index, length, text); var result = arr.join(""); document.getElementById('output').innerHTML = result; console.log(result); } dothis(); <input id="x" type="text" value="White Dog" placeholder="Enter Text" /> <input id="index" type="number" min="0"value="6" style="width:50px" placeholder="index" /> <input id="length" type="number" min="0"value="1" style="width:50px" placeholder="length" /> <input id="text" type="text" value="F" placeholder="New character" /> <br> <button id="submit" onclick="dothis()">Run</button> <p id="output"></p>

此方法适用于较小长度的字符串，但对于较大的文本可能很慢。

var x = "White Dog";
var arr = x.split(""); // ["W", "h", "i", "t", "e", " ", "D", "o", "g"]
arr.splice(6, 1, 'F');

/* 
  Here 6 is starting index and 1 is no. of array elements to remove and 
  final argument 'F' is the new character to be inserted. 
*/
var result = arr.join(""); // "White Fog"

你不能。取位置前后的字符并连接成一个新字符串:

var s = "Hello world";
var index = 3;
s = s.substring(0, index) + 'x' + s.substring(index + 1);

在JavaScript中，字符串是不可变的，这意味着您所能做的最好的事情就是用更改后的内容创建一个新的字符串，并将变量赋值指向它。

你需要自己定义replace()函数:

String.prototype.replaceAt = function(index, replacement) {
    return this.substring(0, index) + replacement + this.substring(index + replacement.length);
}

像这样使用它:

var hello = "Hello World";
alert(hello.replaceAt(2, "!!")); // He!!o World

str = str.split('');
str[3] = 'h';
str = str.join('');