Swift 3 &自动布局兼容版本:

class InsetLabel: UILabel {

    var insets = UIEdgeInsets()

    convenience init(insets: UIEdgeInsets) {
        self.init(frame: CGRect.zero)
        self.insets = insets
    }

    convenience init(dx: CGFloat, dy: CGFloat) {
        let insets = UIEdgeInsets(top: dy, left: dx, bottom: dy, right: dx)
        self.init(insets: insets)
    }

    override func drawText(in rect: CGRect) {
        super.drawText(in: UIEdgeInsetsInsetRect(rect, insets))
    }

    override var intrinsicContentSize: CGSize  {
        var size = super.intrinsicContentSize
        size.width += insets.left + insets.right
        size.height += insets.top + insets.bottom
        return size
    }
}

Swift 4版的blyabtroi解决方案

let leadingMargin: CGFloat = 10
let trailingMargin: CGFloat = 10

let style = NSMutableParagraphStyle()
style.alignment = .justified
style.firstLineHeadIndent = leadingMargin
style.headIndent = leadingMargin
style.tailIndent = trailingMargin

label.attributedText = NSAttributedString(string: "Label with margins", 
                                          attributes: [NSAttributedStringKey.paragraphStyle: style])

设置标签的textAlignment属性为NSTextAlignmentRight并增加它的宽度。

如果是单行，只需在左侧添加空格，超过一行的填充将再次为0。

[self.myLabel setText:[NSString stringWithFormat:@"   %@", self.myShortString]];

对于Xamarin用户(使用统一API):

class UIMarginLabel : UILabel
{
    public UIMarginLabel()
    {
    }

    public UIMarginLabel( CGRect frame ) : base( frame )
    {
    }

    public UIEdgeInsets Insets { get; set; }

    public override void DrawText( CGRect rect )
    {
        base.DrawText( Insets.InsetRect( rect ) );
    }
}

对于那些使用原始MonoTouch API的人:

public class UIMarginLabel : UILabel
{
    public UIEdgeInsets Insets { get; set; }

    public UIMarginLabel() : base()
    {
        Insets = new UIEdgeInsets(0, 0, 0, 0);
    }
    public UIMarginLabel(RectangleF frame) : base(frame)
    {
        Insets = new UIEdgeInsets(0, 0, 0, 0);
    }

    public override void DrawText(RectangleF frame)
    {
        base.DrawText(new RectangleF(
            frame.X + Insets.Left,
            frame.Y + Insets.Top,
            frame.Width - Insets.Left - Insets.Right,
            frame.Height - Insets.Top - Insets.Bottom));
    }
}

blyabtroi的asnwer在Swift中转换(不需要子类化)

let style: NSMutableParagraphStyle = NSParagraphStyle.defaultParagraphStyle().mutableCopy() as! NSMutableParagraphStyle
style.alignment = .Justified
style.firstLineHeadIndent = 10.0
style.headIndent = 10.0
style.tailIndent = -10.0
let attrText: NSAttributedString = NSAttributedString(string: title, attributes: [NSParagraphStyleAttributeName:style])
let label: UILabel = UILabel(frame: someFrame)
label.numberOfLines = 0
label.attributedText = attrText