C# / Xamarin：

segment.SetTitleTextAttributes(new UITextAttributes { 
    Font = UIFont.SystemFontOfSize(font_size) }, UIControlState.Normal);

 UISegmentedControl.appearance().setTitleTextAttributes(NSDictionary(objects: [UIFont.systemFont(ofSize: 16.0)],
                                                                        forKeys: [kCTFontAttributeName as! NSCopying]) as? [AnyHashable : Any],
                                                           for: UIControlState.normal)

在swift 5中，

let font = UIFont.systemFont(ofSize: 16)
UISegmentedControl.appearance().setTitleTextAttributes([NSAttributedString.Key.font: font], for: .normal)

以下是Swift版本的公认答案:

斯威夫特3:

let font = UIFont.systemFont(ofSize: 16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font],
                                        for: .normal)

斯威夫特2.2:

let font = UIFont.systemFontOfSize(16)
segmentedControl.setTitleTextAttributes([NSFontAttributeName: font], 
    forState: UIControlState.Normal)

另一种选择是对控件应用转换。然而，它将缩小一切，包括控制边界。

segmentedControl.transform = CGAffineTransformMakeScale(.6f, .6f);

这是为objective - c添加你的分段控件名称来代替mysegmentedcontrol

UIFont *font = [UIFont systemFontOfSize:11.0f];

NSDictionary *attributes = [NSDictionary dictionaryWithObject:font
                                                            forKey:UITextAttributeFont];

[mySegmentedcontrol setTitleTextAttributes:attributes                                    forState:UIControlStateNormal];

希望能有所帮助